Ctcf and ctcfl in cancer

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August undefined, 2024

WebFeb 16, 2024 · CTCF overexpression has been identified in breast cancer , cervical cancer , ovarian cancer , and hepatocellular carcinoma . Some mutations are related to tumors ( 15 ). In particular, hotspot binding site mutations occur at quite a high frequency (25%) in GC, and these mutations are associated with alterations in gene expression ( 16 ). WebMay 11, 2024 · Ubiquitously expressed CTCF is involved in numerous cellular functions, such as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is …

The epigenetic factor BORIS (CTCFL) controls the …

WebSep 15, 2024 · Background: The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome … WebApr 1, 2024 · CTCF and CTCFL contain N-terminal and C-terminal domains and a central 11-zinc finger region. CTCF binds to approximately 80 000 sites on mammalian … the freeze game on youtube

Cancer-specific CTCF binding facilitates oncogenic …

http://www.cancerindex.org/geneweb/CTCFL.htm WebResearch to identify CTCFL as a biomarker for specific cancer types and for therapeutical approaches has been followed up . With the advent of next-generation-sequencing many advances in the field of DNA binding factors have been made. ... CTCF/CTCFL co-bound and CTCF or CTCFL stand-alone sites) and the average CTCF site as reference were ... WebAug 31, 2016 · A common aberration in cancer is the activation of germline-specific proteins. The DNA-binding proteins among them could generate novel chromatin states, not found in normal cells. The germline-specific transcription factor BORIS/CTCFL, a paralog of chromatin architecture protein CTCF, is often erroneously activated in cancers and … the freeze in chestertown md

Ctcf and ctcfl in cancer

Molecular Lesions of Insulator CTCF and Its Paralogue CTCFL

WebSep 15, 2024 · Specific CTCF binding events occur in human cancers. Cancer-specific CTCF binding can be induced by other transcription factors to regulate oncogenic gene …

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WebMar 3, 2024 · An expanding literature describes a cancer-associated role for BRD8 (reviewed in (Fujisawa and Filippakopoulos, ... Since BRD8 is not predicted to bind directly to DNA, an association with CTCF/CTCFL could be an effective route to achieving chromatin proximity (Pena-Hernandez, Marques, Hilmi et al., 2015). To further explore … WebNov 15, 2013 · Estrogens play a key role in breast cancer, with 60–70% of the cases expressing estrogen receptors (ERs), which are encoded by the ESR1 gene. CTCFL, a paralogue of the chromatin organizer CTCF, is a potential biomarker of breast cancer, but its expression in this disease is currently controversial.

WebNov 2, 2024 · However, in cancer, CTCF is substituted by CTCFL/BORIS, depicted as a blue circle, shutting down the transcription of these tumor suppressor genes through activation of anti-sense transcripts. The … WebMar 30, 2024 · Here, we show that MYC reshapes the chromatin architecture of prostate cancer (PCa) cells through interacting with CTCF protein. By defining H3K27ac, AR and CTCF HiChIP profiles and CRISPR ...

WebFeb 7, 2024 · The oncogene CTCFL (BORIS), the paralog of CTCF, is a transcriptional factor highly expressed in ovarian cancer (but in rarely any other tissue in females) with cancer-specific characteristics and ... WebNov 2, 2024 · However, in cancer, CTCF is substituted by CTCFL/BORIS, depicted as a blue circle, shutting down the transcription of these tumor suppressor genes through activation of anti-sense transcripts. The …

WebCTCFL is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes. ... BORIS like protein; BORIS-like protein; Brother of the regulator of imprinted sites; Cancer/testis antigen 27; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein)-like; CCCTC-binding factor like; CT27; CTCF paralog; CTCF T; …

WebOct 5, 2024 · BORIS (CTCFL) is a DNA binding protein which is involved in tumorigenesis. Although, there are different opinions on the level of gene expression and function of BORIS in normal and cancer tissues, the results of many studies have classified BORIS as a protein belonging to cancer/testis (CT) genes, which are identified as a group of genes … the freeze in edgeley ndWebApr 13, 2024 · MYC reshapes CTCF-mediated chromatin architecture in prostate cancer. April 13, 2024. MYC is a well characterized oncogenic transcription factor in prostate … the freeze in atlantaWebMay 4, 2024 · In recent years, the most extensively studied disease related to CTCF protein is cancer. Debaugny and Skok reviewed the oncogenic roles of CTCF and CTCFL (CTCF-like or BORIS; the paralog of CTCF, see below section for BORIS). Human IDH gene mutant gliomas exhibit DNA hypermethylation, which ... the adult adhd self report scaleWebIn ovarian cancer CTCFL expression indeed correlates with advanced stage and decreased survival . In other tumor types CTCFL expression has also been detected, although expression data have been contradictory . According to the TCGA data, CTCFL is mainly expressed in ovarian cancer (Supplementary Figure 2). the adult adhd self-report scale asrsWebIn ovarian cancer CTCFL expression indeed correlates with advanced stage and decreased survival . In other tumor types CTCFL expression has also been detected, although … the freeze in conway scWebCCCTC-binding factor ( CTCF ), an 11- zinc finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive … the freeze grayslakeWebSep 15, 2024 · Identification of cancer-specific CTCF binding patterns in the human genome. a Distribution of coefficient of variation of chromatin accessibility at different genomic features, calculated using DNase-seq data from over 60 cell lines from ENCODE.b Distribution of occupancy score for all 688,429 union CTCF binding sites (blue), and … the freeze incredibles