Eleutherobin
WebEleutherobin is a competitive inhibitor of Taxol binding to tubulin, thereby enhancing tubulin assembly and stability. The in vitro cytotoxicity towards human tumour cell lines (IC 50 10 nM – 60 nM) is comparable to that of Epothilone A with Sarcodictyins A and B being at least 10 times less potent [ 119 ]. WebMar 15, 1998 · Eleutherobin is a novel natural product isolated from a marine soft coral that is extremely potent for inducing tubulin polymerization in vitro and is cytotoxic for cancer …
Eleutherobin
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WebAbstract: Eleutherobin and dictyostatin are antimitotic compounds which exert their cyto- toxic activity by a taxol-like mode of action, i.e., hypernucleating tubulin assembly and in- … WebEleutherobin is highly cytotoxic to cancer cells with IC 50 values in the range of 10–15 nM. It acts similar to paclitaxel by inducing tubulin polymerization. Analogs of eleutherobin …
WebApr 1, 2006 · The seeds have been used in alternative medicine as a laxative, in colic treatment and as a breath freshener, even being safe to add to young children’s dishes to help digestion. The seeds have been found to have antipasmodic, carminative, emmenagogue, expectorant, galactagogue, stimulant, stomachic and tonic properties. WebMay 23, 2024 · Eleutherobin is used by soft corals as a defence against predators, with the chemical disrupting the cytoskeleton – a key scaffold in cells. However, laboratory studies have shown that the ...
WebThe total synthesis of the cytotoxic marine natural products eleutherobin (1) and eleuthosides A (2) and B (3) is described. The strategy involves glycosidation of the (+)-carvone-derived intermediate 7 with the arabinose-derived trichloroacetimidate 9 followed by base-induced ring closure and elaboration to afford the dihydroxy eneynone 19. WebMay 1, 2000 · Eleutherobin displayed cross-resistance in multidrug resistant cell lines, an effect that was reversible by verapamil, suggesting that eleutherobin is a substrate of P-glycoprotein . Although there are no clinical data available to date on the therapeutic activity of these new antimitotic agents, it is their distinct chemical structures and ...
WebApr 16, 2001 · Eleutherobin (1), isolated by Fenical and coworkers from the Western Australian soft coral Eleutherobia sp., belongs to a small family of soft coral diterpenoids …
WebRecently, three natural products have been identified, the epothilones, eleutherobin, and discodermolide, whose mechanism of action is similar to that of Taxol in that they stabilize microtubules and block cells in the mitotic phase of the cell cycle. In this report, we have compared and contrasted … how much sheba to feed my catWebApr 27, 1999 · Effects of eleutherobin did not differ greatly from those of paclitaxel and epothilone A. Eleutherobin and epothilone A were competitive inhibitors of the binding of radiolabeled paclitaxel to tubulin polymer (apparent Ki … how do smithing stones workWebEleutherobin is a potent β-microtubule inhibitor with an IC50 value of 2 μM. Eleutherobin can be isolated from a marine soft coral. Eleutherobin has cytotoxic activity against cancer cells with similar potency to that of Paclitaxel (HY-B0015). Anticancer activity. For research use only. We do not sell to patients. Eleutherobin Chemical Structure how do smartwatches track sleepWebMar 15, 1998 · Eleutherobin is a novel natural product isolated from a marine soft coral that is extremely potent for inducing tubulin polymerization in vitro and is cytotoxic for cancer cells with an IC50... how do smoke curtains workWebBlock user. Prevent this user from interacting with your repositories and sending you notifications. Learn more about blocking users.. You must be logged in to block users. how much shedding is too muchWebDec 1, 1997 · Taxol-like activity is exhibited by eleutherobin ( 1 ), one of the most promising antitumor agents isolated from nature in recent years. The first total synthesis of this … how do smoke eaters workWebAnalogs of sarcodictyin and eleutherobin US6172205B1 (en) * 1997-12-11: 2001-01-09: The Trustees Of Columbia In The City Of New York: Synthetic process toward total synthesis of eleutherobin and its analogues and uses thereof US6858598B1 (en) 1998-12-23: 2005-02-22: G. D. Searle & Co. how do smoke machines work