WebFIGURE 1: Predicted topological model of P4-ATPase and its regulatory subunit Cdc50. Cdc50 interacts with P4-ATPase through its exocytoplasmic loop to activate the lipid flippase function, which translocates specific phospholipids from the exocytoplasmic leaflet to the cytoplasmic leaflet of the lipid bilayer membrane. WebApplication. Anti-ABCA4, clone 3F4, Cat. No. MABN2439, is a highly specific mouse monoclonal antibody that targets ABCA4 (RIM) and has been tested in …
Neurobiology: Ferroportin and Exocytoplasmic …
WebAug 28, 2024 · A number of disease-associated mutations in the exocytoplasmic domains (ECDs), the nucleotide-binding domains (NBDs), and the C-terminal segment of ABCA4 have been previously characterized (Sun, Smallwood et al. 2000, Wiszniewski, Zaremba et al. 2005, Zhong, Molday et al. 2009, Quazi and Molday 2013, Zhang, Tsybovsky et al. … WebECD: exocytoplasmic domain; TMD: transmembrane domain; S-S: disulfide bond; NBD: nucleotide-binding domain; ATP: adenosine triphosphate; ADP: adenosine diphosphate; … self proving will nc
The pathological significance and potential mechanism of
WebJul 9, 2009 · The precise role of SS in activation and maintenance of the translocation process/machinery has remained obscure except that either during or following complete polypeptide translocation, the transposed SS is cleaved off by an exocytoplasmic Spase to generate the mature region. WebCC-preferring endodeoxyribonuclease ( EC 3.1.21.6, Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease) is an enzyme. [1] [2] This enzyme catalyses the following chemical reaction endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC WebABCA4, also known as the Rim protein and ABCR, is a large 2,273 amino acid glycoprotein organized as two tandem halves, each containing a single membrane spanning segment followed sequentially by a large exocytoplasmic domain, a multispanning membrane domain and a nucleotide binding domain. self provisioning costs