He and klionsky fundc1
Web本项目将研究FUNDC1参与线粒体形态变化的分子机制，阐明FUNDC1参与线粒体形态调控和线粒体自噬相互关系。 并利用FUNDC1敲减或敲除的细胞，进一步研究线粒体分裂和自噬在细胞凋亡调控中可能的作用。 本项目的实施将进一步明确FUNDC1的新功能，并对线粒体形态变化，线粒体自噬和细胞凋亡的相互关系提供新的启示。 英文摘要 The balance … Web16 de dic. de 2024 · In addition, FUNDC1 can be enriched at contact sites between mitochondria and the endoplasmic reticulum (ER), determining the formation of mitochondria-associated membranes (MAMs) that regulate cellular calcium (Ca 2+) homeostasis and mitochondrial dynamics to prevent heart dysfunction.
He and klionsky fundc1
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WebAn X-linked lysosomal storage disease marked by progressive symptoms including burning pain in the hands and feet, sweating, and purple skin lesions, with death resulting from … WebFUN14 Domain-Containing 1 (FUNDC1) is a new type of mitochondrial membrane protein that mediates mitochondrial autophagy in mammalian cells, it mainly acts in controlling mitochondrial autophagy by regulating the phosphorylation level of FUNDC1 on the mitochondrial membrane.
Web22 de ene. de 2012 · Chen and colleagues show that FUNDC1, an integral mitochondrial outer membrane protein, interacts with light chain 3 (LC3) and is essential for hypoxia … Web26 de mar. de 2014 · The mitophagy receptor FUNDC1 is a novel substrate of ULK1 and FUNDC1 (N118A) that prevents its binding to ULK1, impairs ULK1 translocation to mitochondria, and inhibits mitophagy A. HeLa cells …
WebFUNDC1 is a membrane protein located in mitochondria. FUNDC1 binds to LC3 through its LIR domain, causing an autophagic bilayer membrane to envelop mitochondria, inducing mitochondrial autophagy. The resulting mitochondrial autophagy inhibits apoptosis and protects neurons. Web8 de may. de 2014 · Interactions between LC3 and mitophagy receptors such as FUNDC1, which harbors an LC3-interacting region (LIR), are essential for this selective process. …
WebDaniel Klionsky, Ph.D. Research Professor, Life Sciences Institute Alexander G. Ruthven Professor of Life Sciences, Department of Molecular, Cell & Developmental Biology, U-M College of Literature, Science, and the Arts (734) 615-6556 [email protected] Research Staff Hana Popelka, Ph.D. Research Laboratory Specialist [email protected]
Web29 de feb. de 2012 · He C, Klionsky DJ. Regulation mechanisms and signaling . pathways of autophagy. Annu Rev Genet 2009;43:67-93. He C, Levine B. The Beclin 1 interactome. Curr Opin Cell Biol . 2010;22:140-9. gamba macchine agricole facebookWebTakeshi Noda 1 , Daniel J Klionsky. Affiliation 1 Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan. PMID: 19185711 DOI: 10.1016/S0076-6879(08)03203-5 Abstract The measurement of ... black crowes lyrics remedyWeb9 de may. de 2024 · Here, we are aimed to explore the role of c-Src (Src) and FUNDC1-related mitophagy in the development of DN. Methods: The db/db mice were used to establish a DN mice model. The mice accepted PP2 (Src inhibitor) treatment to study the role of Src in DN. Kidney function was measured via biochemical testing. black crowes manchesterblack crowes madrid 2021Web11 de abr. de 2024 · FUNDC1 is a mitochondrial receptor for hypoxia-induced mitophagy, which can be negatively regulated by Src kinase and casein kinase 2 . black crowes manchester 2022 reviewWeb10 de may. de 2024 · FUN14 domain-containing protein 1 (FUNDC1) is an integral mitochondrial outer-membrane protein, and mediates the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs). This ... black crowes managementWeb10 de may. de 2024 · FUN14 domain-containing protein 1 (FUNDC1) is an integral mitochondrial outer-membrane protein, and mediates the formation of mitochondria … gambals westport