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WebFeb 15, 2024 · Baicalin regulated TGF-β/Smads pathway through AMPK activation. Rat cardiac fibroblasts treated with Compound C were pretreated with 50 μM baicalin or 1 mM AICAR for 1 h followed by stimulation with Ang Ⅱ for 24 h (A–E) The protein expression of TGF-β, p-Smad2, Smad2, p-Smad3, Smad3, Smad4 and β-actin were detected by Western … WebAug 31, 2024 · activate the BMP-2/Smads/Runx2 signal pathway for increasing both the proliferation and differentiation of the MC3T3-E1 cells. However, the osteogenic effects of icariin can be suppressed by the BMP-2 antagonist (Noggin). In conclusion, we demonstrate that icariin is an osteoinductive factor that exerts its osteogenic effect by regulating the WebJ Cancer 2024; 9(21):4018-4028. doi:10.7150/jca.20906 This issue Cite. Review. Roles of Smads Family and Alternative Splicing Variants of Smad4 in Different Cancers . Irfan Ullah 1, Weichao Sun 1, Liling Tang 1 , Jianguo Feng 2 . 1. Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing … can steven johnson syndrome be cured