Klf5 gastric cancer

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August undefined, 2024

WebApr 24, 2024 · The function of KLF5 in cell proliferation was studied in gastric cancer cell lines and organoids. We found that KLF5 amplification mainly occurred in the chromosome instable tumors (CIN) and was significantly associated with TP53 mutation. In addition, higher KLF5 expression correlated with more locally invasive gastric cancer and higher T …

A comprehensive survey of genomic alterations in gastric cancer …

WebGastric cancer; KLF5; CCL5; CCR5 Introduction Gastric cancer is a leading cause of cancer-related death in the world.1 It was widely considered that genetic mutations and epigenetic alterations of oncogenes and tumor suppressor genes were closely associated with the initiation and development of human gastric cancer,2 but the actual molecular ... WebThe regulation of KLF5 on expression levels of p21 and CDK4 in GC cells was determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) and Western blot. Results: … diclofenac modified release spc

8 Warning Signs of Stomach Cancer and How to Prevent It

WebKLF5. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC. WebOct 27, 2024 · KLF5 has been reported as a lineage-survival oncogene whose expression is upregulated in specific cancer types, such as squamous carcinoma (e.g., head and neck … WebKrüppel-like factors (KLFs), such as KLF4, KLF2, KLF5 and KLF15, have been extensively investigated in multi-cancers. However, KLF16, a member of KLFs, hasn't been well identified in cancer, especially in gastric cancer (GC). Here, we investigated the roles of KLF16 in GC. In present study, we found that KLF16 expression levels were ... city centre hotel gyms shaniwarwada fort pune

Exploring the Difference Between Gastric Cardia Cancer and Non …

Acetylation of KLF5 maintains EMT and tumorigenicity to cause ...

WebFeb 15, 2024 · KLF5 and MYC modulated LINC00346 contributes to gastric cancer progression through acting as a competing endogeous RNA and indicates poor outcome Cell Death & Differentiation Article 15... WebApr 13, 2024 · 5. Diet. Pickled, salted, and smoked foods can increase the risk of stomach cancer. Fresh fruits and vegetables can lower the risks. 6. Helicobacter Pylori Infection. This bacteria causes ... city centre hotel gyms in nrg stadium houstonWebResults 22 recurrent focal alterations (13 amplifications and nine deletions) were identified. These included both known targets (FGFR2, ERBB2) and also novel genes in gastric cancer (KLF5, GATA6).Receptor tyrosine kinase (RTK)/RAS alterations were found to be frequent in gastric cancer. This study also demonstrates, for the first time, that these alterations … city centre hotel gyms nurimaru apec house

"WebTo define the role of KLF5 within the context of H. pylori-induced inflammation and injury, human gastric epithelial cells were co-cultured with the wild-type cag+ H. pylori strain 60190. " - Klf5 gastric cancer

Klf5 gastric cancer

Down-regulation of KLF5 in cancer-associated fibroblasts …

WebMar 19, 2024 · KLF5 expression was positively related to B cells, CD8+ T cells, and macrophages in rectal cancer. In addition, KLF15 was shown to be positively linked with CD4+ T cell and macrophage levels in colon cancer patients but not in rectal cancer patients. Figure 7 WebSep 7, 2024 · KLF5 is a member of the Kruppel-like factor, subfamily of zinc finger proteins that are involved in cancers. KLF5 functions as a transcription factor and regulates the diverse protein-coding genes (PCGs) in colorectal cancer (CRC). However, the long non-coding RNAs (lncRNAs) regulated by KLF5 in CRC are currently unknown. Methods

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WebKLF5 is involved in the initiation and development of diverse cancers in a context-dependent manner. KLF5 promotes several cancers, such as breast cancer, CRC, bladder cancer, and … Web1 day ago · “The 5-year survival rate for patients diagnosed with metastatic gastric cancer is estimated to be only 6%, and 80% of patients with locally advanced unresectable or metastatic gastric or ...

WebLi-Fraumeni syndrome [ 82 ] Inherited mutation in TP53 gene.Affected family members at increased risk of bone tumors, breast cancer, leukemia, brain tumors, and sarcomas.17p13. 1 P53 DNA damage response Paget disease [ 83 ] Excessive ... WebGastric cancer; KLF5; CCL5; CCR5 Introduction Gastric cancer is a leading cause of cancer-related death in the world.1 It was widely considered that genetic mutations and …

WebJul 6, 2011 · In gastric cancer, the survival time of patients with higher levels of KLF5 was shown to be longer than that of patients with low levels of KLF5 . The overexpression of KLF5 inhibits the colony formation ability of the T-47D breast cancer cell line and reduces the proliferation of TE2 esophageal cancer cells [ 1 , 13 ]. WebThe Krüppel-like factor 5 (KLF5), a zinc-finger transcriptional factor, is highly expressed in several solid tumors, but its role in PTC remains unclear. ... Among the 1198 metastatic gastric cancer patients who started therapy within six months after metastasis detection, 87 were initially treated with trastuzumab-based chemotherapy and 1111 ...

WebFeb 15, 2024 · KLF5 and MYC modulated LINC00346 contributes to gastric cancer progression through acting as a competing endogeous RNA and indicates poor outcome …

WebAbstract. Intestinal metaplasia (IM) is the inevitable precancerous stage to develop intestinal-type gastric cancer (GC). Deoxycholic acid (DCA) is the main bile acid (BA) component of duodenogastric reflux and has shown an increased concentration during the transition from chronic gastritis to IM associated with continued STAT3 activation. diclofenac lower back spasmsWebSep 10, 2024 · Ma and colleagues demonstrated the functions and mechanism of lncRNA NEAT1 in gastric cancer tumorigenesis. NEAT1, which was induced by KLF5, promoted cell proliferation and inhibited apoptosis. Mechanistically, NEAT1 bound BRG1 directly, modulating histone methylation modification to regulate GADD45A-dependent G2/M cell … diclofenac mood 75 mkWebThe overexpression of KLF5 in gastric cancer stroma is related to poor patient prognosis. The tissue microarray contains 120 gastric cancer tissues after radical surgery were … city centre hotel gyms osaka jpWebJul 27, 2024 · KLF5 promotes the proliferation of gastric cancer cells and the expression of metastasis-related molecules. Conclusion KLF4 and KLF5 are of great significance for … diclofenac mylan 75 mgWebApr 30, 2024 · For instance, KLF5-activated lncRNA NEAT1 accelerated gastric cancer progression via serving as a scaffold for BRG1 to down-regulate GADD45A expression . KLF5-regulated lncRNA RP1 contributed to cell proliferation and metastasis in breast cancer through suppressing p27kip1 translation . Overall, the abnormal increase of BBOX1-AS1 … diclofenac is what type of drugWebOct 26, 2024 · We investigated the expression of KLF5 and miR-145-5p messenger RNA (mRNA) in gastric cancer and then analyzed its role in the biological behavior of gastric … city centre hotel gyms tokyo imperial palaceWebSep 7, 2024 · KLF5 is a member of the Kruppel-like factor, subfamily of zinc finger proteins that are involved in cancers. KLF5 functions as a transcription factor and regulates the … diclofenac in pill form