WebShumiya cataract rat (SCR) is a hereditary cataractous rat strain that develops cataract at approximate 11 weeks of age . Lss gene is mutated in SCR and is the major gene for cataract onset [ 19 ]. In humans, two distinct homozygous LSS missense mutations (W581R and G588S) happen in two families with extensive congenital cataracts, which impairs key … WebJul 21, 2024 · We previously designed ophthalmic nanosuspensions of LAN (LAN-ONSs) and reported that repeated instillation of LAN-ONSs attenuated the slight collapse of the lens structure in Shumiya cataract rats (SCR), although the serious structural collapses were not reversed with the instillation of LAN-ONSs, and repeated instillation could not reverse or ...
Comparison of the Mechanisms of Cataract Development …
WebJun 23, 2024 · The Shumiya cataract rat (SCR) is a model for hereditary cataract. Two-thirds of these rats develop lens opacity within 10-11 weeks. Onset of cataract is attributed to the synergetic effect of lanosterol synthase (Lss) and farnesyl-diphosphate farnesyltransferase 1 … WebApr 1, 2007 · Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat. Mori M, Li G, Abe I, Nakayama J, Guo Z, Sawashita … the midnight club episode 5 recap
Establishment of the hereditary cataract rat strain (SCR) and
WebA new cataractous rat strain, Shumiya Cataract Rat (SCR), which was derived from the cross-breeder formed between the spontaneous hypertensive rat and the Zucker fatty rat, … WebThe role of proteolytic enzymes in Shumiya cataract rats in alterations to lens proteins during cataract formation was studied immunohistochemically using antibodies against exopeptidases, such as lysosomal dipeptidyl peptidase II (DPP II), cytosolic dipeptidyl peptidase III, and soluble and membrane-bound alanyl aminopeptidases, and against … WebSpecifically, hypomorphic LSS and farnesyl diphosphate farnesyl transferase 1 (FDFT1) mutations lower cholesterol and induce cataracts in the Shumiya cataract rat . More recently, Zhao et al. [47] identified two novel LSS mutations, G588S and W581R, from those with congenital cataracts, and treatment with lanosterol eye drops was shown to … the midnight club egybest